Villanova Monteleone () is a comune (municipality) in the Metropolitan City of Sassari in the Italian region Sardinia, located about northwest of Cagliari and about southwest of Sassari. As of 31 December 2004, it had a population of 2,528 and an area of .
Villanova Monteleone borders the following municipalities: Alghero, Bosa, Ittiri, Monteleone Rocca Doria, Montresta, Padria, Putifigari, Romana, Thiesi.