Villanova Marchesana is a comune (municipality) in the Province of Rovigo in the Italian region Veneto, located about southwest of Venice and about southeast of Rovigo. As of 31 December 2004, it had a population of 1,109 and an area of .
The municipality of Villanova Marchesana contains the frazioni (subdivisions, mainly villages and hamlets) Ca' de Rusco, Canalazzo, Canalnuovo, Capo di Sopra, , Cisimatti, and Ponte.
Villanova Marchesana borders the following municipalities: Adria, Berra, Crespino, Gavello, Papozze.