Villafranca Sicula is a comune (municipality) in the Province of Agrigento in the Italian region Sicily, located about south of Palermo and about northwest of Agrigento. As of 31 December 2004, it had a population of 1,496 and an area of .
Villafranca Sicula borders the following municipalities: Burgio, Calamonaci, Caltabellotta, Lucca Sicula.
The Roman Catholic cardinal Salvatore Pappalardo (1918âÂÂ2006), archbishop emeritus of Palermo, is a well-known native of Villafranca Sicula.