Villa di Serio (Bergamasque: ) is a comune (municipality) in the Province of Bergamo in the Italian region of Lombardy, located about northeast of Milan and about northeast of Bergamo. As of 31 December 2004, it had a population of 6,118 and an area of .
The municipality of Villa di Serio contains the frazione (subdivision) Rinnovata.
Villa di Serio borders the following municipalities: Alzano Lombardo, Nembro, Ranica, Scanzorosciate.