Villa Anneslie is a historic home located at Towson, Baltimore County, Maryland, United States. It was built about 1855 as a summer home. Designed by architect John Rudolph Niernsee, it is an Italianate two-story villa built in brick and covered in clapboard. It features an asymmetrical design with a central three story tower over the entrance.
Villa Anneslie was listed on the National Register of Historic Places in 1977.