Vicopisano is a comune (municipality) in the Province of Pisa in the Italian region Tuscany, located about west of Florence and about east of Pisa. It occupies the former valley of the Arno River (which now flows some km southwards), bounded by the Monte Pisano from north.
In medieval times Vicopisano was a flourishing fortified center of the Republic of Pisa. It was conquered by Florence in 1406. Here a castle (Rocca Nuova) designed by Filippo Brunelleschi was built in 1434. The Pieve di Santa Maria is a 12th-century parish church built in Romanesque style.
Vicopisano borders the following municipalities: Bientina, Buti, Calci, Calcinaia, Cascina and San Giuliano Terme. It counts the hamlets (frazioni) of Caprona, Cucigliana, Lugnano, Noce, San Giovanni alla Vena and Uliveto Terme.
Economical activities include ceramics, mechanics (Piaggio) and bottling of mineral waters. The agriculture is based on olive oil and cereals.