The Apostolic Vicariate (Vicariate Apostolic) of Aguarico (), a missionary s-circonscription of the Roman Catholic Church, is located in the Aguarico Canton in Ecuador's Amazon rainforest.
On 16 November 1953 Pope Pius XII established the Apostolic prefecture of Aguarico from the Apostolic Vicariate of Napo. It has a cathedral see, the Catedral Nuestra Señora del Carmen, in Puerto Francisco de Orellana, in Orellana Province.
Pope John Paul II elevated it to a Apostolic vicariate on 2 July 1984.
It remains exempt, i.e., immediately subject to the Holy See, not part of any ecclesiastical province.
So far, all ordinaries have been Capuchins.