Vezzano sul Crostolo (Reggiano: ) is a comune (municipality) in the Province of Reggio Emilia in the Italian region Emilia-Romagna, located about west of Bologna and about southwest of Reggio Emilia.
Vezzano sul Crostolo borders the following municipalities: Albinea, Casina, Canossa, Quattro Castella, San Polo d'Enza, Viano.