Vexillum macrospira is a species of sea snail, a marine gastropod mollusk, in the family Costellariidae, the ribbed miters.
The length of the shell attains 33 mm.
A whitish, pyramidal-turreted species with a produced acuminate spire. It is ornated with irregular rows of chestnut spots. The whorls are slightly convex with longitudinal smooth ribs. The short aperture has a narrowed base. The outer lip is dilated anteriorly. The columella is five-plaited.
The shell is whitish or yellowish, with rows of chestnut spots.
This marine species occurs off India.