Verkhneye Isakovo () is a rural locality (a village) in Yenangskoye Rural Settlement, Kichmengsko-Gorodetsky District, Vologda Oblast, Russia. The population was 1 as of 2002.
Verkhneye Isakovo is east of Kichmengsky Gorodok (the district's administrative centre) by road. Podgorye is the nearest rural locality.