Verkhnedonskoy District () is an administrative and municipal district (raion), one of the forty-three in Rostov Oblast, Russia. It is located in the north of the oblast. The area of the district is . Its administrative center is the rural locality (stanitsa) of Kazanskaya. Population: 20,441 (2010 Census); The population of Kazanskaya accounts for 23.1% of the district's total population.