The Varzob (, in the lower reaches also Dushanbinka) is a right tributary of the river Kofarnihon in Tajikistan. It is long and has a basin area of .
The Varzob rises on the southern flank of the Gissar Mountains, and flows south. It passes through the Varzob District, the town Varzob and through the Tajik capital Dushanbe.