Uromastyx macfadyeni, also known commonly as Macfadyen's mastigure, is a species of lizard in the family Agamidae. The species is endemic to Somalia.
The specific name, macfadyeni, is in honor of British geologist William Archibald Macfadyen.
The preferred natural habitat of Uromastyx macfadyeni is stony shrubland, at altitudes of .
Uromastyx macfadyeni is terrestrial and diurnal. It shelters beneath stones and in crevices of stones.