Upper Nine Mile River is an unincorporated community in the Canadian province of Nova Scotia, located in East Hants Municipality in Hants County.
Evan MacKay received a land grant in Upper Nine Mile River on 12 November 1828.
A cheese factory began operating in Upper Nine Mile River in May 1892, known as the Little River Cheese Manufacturing Company. This factory inspired the name of Cheese Factory Corner, now a locality of Upper Nine Mile River. The locality of Roulston Corner is also located within the community limits of Upper Nine Mile River.