Upper Esk is a rural locality in the local government areas (LGA) of Break O'Day and Dorset in the North-east LGA region of Tasmania. The locality is about southeast of the town of Scottsdale.
Upper Esk was gazetted as a locality in 1976.
The name was changed from Cloverdale in 1948.
The 2016 census recorded a population of 26 for the state suburb of Upper Esk. At the , the population had dropped to 25.
The South Esk River rises in the north of the locality and flows through to the east.
Route C401 (Upper Esk Road / Gunns Road) passes through from east to west before forming part of the western boundary. Route C423 (Mathinna Plains Road) runs along part of the eastern boundary.