Upernivik Island () is an uninhabited island in Avannaata municipality in northwestern Greenland.
Upernivik Island is located in the Uummannaq Fjord where it is the largest island with an area of .
The island is very mountainous. Its highest point is Palup Qaqaa, an ultra-prominent peak at 71ð 20' 24 N, 52ð 48' 37 W reaching .