The University Clinical Center of the Republika Srpska () is a medical centre located in Banja Luka, Bosnia and Herzegovina. It serves as the main medical centre for both Banja Luka and Republika Srpska.
The University Clinical Center of the Republika Srpska was established in 1897. In August 2015, by the government decision its name was changed to University Clinical Center of the Republika Srpska. It is the largest hospital in Republika Srpska, an entity of Bosnia and Herzegovina. As of 2016, the Clinical Center has 1,243 available beds.