The United States competed at the 2022 World Aquatics Championships in Budapest, Hungary from 18 June to 3 July.
On May 19, 2022, 16 athletes were named to the World Championships roster.
Men
Women
Mixed
On May 28, 2022, 9 athletes were named to the world championships roster.
On May 1, 2022, 41 athletes were named to the World Championships roster. On May 5, the final roster additions were announced.
<small> Legend: (*) = Swimmers who participated in the heat only.</small>