The United States sent a delegation to compete at the 2004 Summer Paralympics in Athens, Greece. A total of 235 U.S. competitors took part in 18 sports; the only sport Americans did not compete in was soccer 5-a-side. The United States finished fourth in the gold and overall medal count, behind China, Great Britain and Canada.
The following American athletes won medals at the games.
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|- |align=left|Aaron Cross |align=left|Men's individual W1 |587 |10 |Bye |<br />L 150-150 |colspan="4"|Did not advance |- |align=left|Jeffrey Fabry |align=left|Men's individual W1 |667 WR |1 |colspan="2"|Bye |<br />W 109-102 |<br />L 108-108 |<br />W 108-96 | |- |align=left|Chuck Lear |align=left|Men's individual W1 |585 |11 |Bye |<br />L 133-150 |colspan="4"|Did not advance |- |align=left|Kevin Stone |align=left|Men's individual W2 |595 |16 |<br />W 147-145 |<br />L 152-162 |colspan="4"|Did not advance |- |align=left|Kevin Stone<br/> Jeffrey Fabry<br/> Aaron Cross |align=left|Men's teams open |1859 |2 |colspan="2"|Bye |<br />W 226-223 |<br />L 0-215 |<br />W 231-212 |
|- |align=left|Lindsey Carmichael |align=left|Women's individual standing |603 WR |1 |N/A |<br />W 145-113 |<br />L 91-98 |colspan="3"|Did not advance
The men's football team didn't win any medals: they were 8th out of 8.
The men's team won a bronze medal in goalball.
The women's team won a silver medal in goalball.
The men's volleyball team didn't win any medals: they were place 6th out of 8.
The women's volleyball team won a bronze medal.
The men's team didn't win any medals. They were 7th out of 12.
The women's team won the gold medal in wheelchair basketball.