The 1968 United States Senate election in Oregon was held on November 5, 1968. Incumbent Democratic U.S. Senator Wayne Morse was seeking a fifth term, but narrowly lost re-election to 36 year-old Republican State Representative Bob Packwood in a very close race.
The general primary was held May 28, 1968. Incumbent Senator Wayne Morse defeated former Representative Robert B. Duncan. Duncan, an outspoken supporter of the Vietnam War, had previously been the Democratic nominee in the 1966 United States Senate election in Oregon, and the anti-war Morse had endorsed Duncan's opponent Mark Hatfield, an anti-war Republican.