The 1988 United States House of Representatives elections in South Carolina were held on November 8, 1988, to select six Representatives for two-year terms from the state of South Carolina. The primary elections for the Democrats and the Republicans were held on June 14. All six incumbents were re-elected and the composition of the state delegation remained four Democrats and two Republicans.
Incumbent Republican Congressman Arthur Ravenel, Jr. of the 1st congressional district, in office since 1987, defeated Democratic challenger Wheeler Tillman.
|- | | colspan=5 |Republican hold |-
Incumbent Republican Congressman Floyd Spence of the 2nd congressional district, in office since 1971, defeated Democratic challenger Jim Leventis.
|- | | colspan=5 |Republican hold |-
Incumbent Democratic Congressman Butler Derrick of the 3rd congressional district, in office since 1975, defeated Republican challenger Henry Jordan.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congresswoman Liz J. Patterson of the 4th congressional district, in office since 1987, defeated Republican challenger Knox White.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman John M. Spratt, Jr. of the 5th congressional district, in office since 1983, defeated Republican challenger Robert K. Carley.
|- | | colspan=5 |Democratic hold |-
Incumbent Democratic Congressman Robin Tallon of the 6th congressional district, in office since 1983, defeated Republican challenger Bob Cunningham.
|- | | colspan=5 |Democratic hold |-