The Embassy of the United States of America in Mexico City () is the diplomatic mission of United States of America to the United Mexican States. The embassy's chancery is situated on the Presa Angostura, Colonia Irrigación, Mexico City. Ronald D. Johnson is the current United States Ambassador to Mexico.
The first U.S. Embassy to open in Mexico City was in January 1899 after the elevation of the American Legation.
The former chancery building began in 1960 and was completed in 1964 at a cost of US$5 million. At the time, it was the second largest United States embassy building in the world.
In 2011, the United States Department of State announced plans to build a new United States embassy in the Nuevo Polanco neighborhood of Mexico City with an initial price of US$763 million. The complex was designed by Tod Williams Billie Tsien Architects and Davis Brody Bond. Construction of the new embassy complex began on February 13, 2018 and was expected to be completed in 2022. After construction delays, the new Chancery was completed in November 2025 at a cost of approximately US$943 million. It is currently the largest U.S. embassy in the world at 530,000 square feet of space.
The Embassy exercises a number of functions in its representation to the Government of Mexico, including political, administrative, economic, public diplomacy and consular affairs, that are managed under the Ambassador by counselors from the U.S. Department of State.
The United States maintains consulates general in Ciudad Juárez, Guadalajara, Hermosillo, Matamoros, Mérida, Monterrey, Nogales, Nuevo Laredo and Tijuana and consular agencies in Acapulco, Los Cabos, Cancún, Mazatlán, Oaxaca City, Piedras Negras, Playa del Carmen, Puerto Vallarta and San Miguel de Allende.