USS Skipjack has been the name of more than one United States Navy ship named after the skipjack tuna, and may refer to:
- USS Skipjack (Submarine No. 24), the original name of a submarine renamed while under construction in 1911 and in commission from 1912 to 1921
- , a submarine in commission from 1938 to 1946
- , a submarine in commission from 1959 to 1990