Three ships of the United States Navy have borne the name USS Reuben James. Reuben James was a boatswain's mate who distinguished himself fighting the Barbary pirates.
- The first , a four-stack , was the first US Navy ship sunk by hostile action in the European Theatre in World War II.
- The second , a , escorted convoys during World War II.
- The third was an guided missile frigate.