USS Jefferson may refer to the following ships operated by the United States:
- , a revenue cutter that served from 1802 until 1817
- , brig that served from 1814 until 1825
- , a revenue cutter that served from 1833 until 1847; her named was changed to Crawford in 1839
- , a revenue cutter that was transferred to the US Coastal Survey in 1848 and wrecked in Patagonia in 1851
See also