UFC 321: Aspinall vs. Gane was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 25, 2025, at the Etihad Arena in Abu Dhabi, United Arab Emirates.
The event marked the promotion's 22nd visit to Abu Dhabi and first since in July 2025.
A UFC Heavyweight Championship bout between current champion Tom Aspinall and former interim champion Ciryl Gane headlined the event.
A UFC Women's Strawweight Championship bout for the vacant title between former Invicta FC Strawweight Champion Virna Jandiroba and Mackenzie Dern took place in the co-main event. Current two-time champion Zhang Weili vacated her title in order to challenge for the UFC Women's Flyweight Championship. The pairing previously met at UFC 256 in December 2020 which Dern won by unanimous decision.
A bantamweight bout between former UFC Bantamweight Championship challenger Umar Nurmagomedov and Mario Bautista took place at this event. They were originally reported to be competing in the main event of one week prior but were moved to this event for unknown reasons.
Abdul-Kareem Al-Selwady and Matheus Camilo were expected to meet in a lightweight bout on the preliminary card, but Al-Selwady pulled out less than 48 hours before the event and the pairing was scrapped.
At the weigh-ins, two fighters missed weight:
Delgado and Maksum's bouts proceeded at catchweight. Both fighters were fined a percentage of their individual purses which went to their opponents Nathaniel Wood (20 percent) and Mitch Raposo (30 percent), respectively.
The following fighters received $50,000 bonuses.