U.S. Route 85 (US 85) is a part of the U.S. Highway System that travels from the Mexican border in El Paso, Texas, north to the Canadian border in Fortuna, North Dakota. In the state of Wyoming, US 85 begins at the Colorado state line south of Cheyenne and ends at the South Dakota state line northeast of Four Corners.
US 85 enters Wyoming from Colorado south of Cheyenne. Just south of the city it joins with US 87 Business, and further north it intersects I-80 where it runs concurrently with I-180, the only fully at-grade Interstate Highway in the U.S. The I-180 concurrency ends at I-80 Business and US 30 in downtown Cheyenne before continuing to I-25 at exit 12. It joins with I-25 and US 87 in a concurrency until US 85 leaves at exit 17 and travels northeast towards Meriden. From there it heads north to Torrington, where it meets with US 26 and runs concurrently for until Lingle. US 85 travels to Lusk where it meets US 20 and US 18. It shares the next with US 18 to Mule Creek Junction, and later meets US 16 near Newcastle. From here it is until it enters South Dakota in the Black Hills.