The George W. Andrews Federal Building and United States Courthouse is a historic government building in Opelika, Alabama. It was originally built in 1915 as the U.S. Post Office. It reflects a Renaissance Revival exterior and Colonial Revival interior.
It is named for George W. Andrews, the pro-racial segregation politician from Alabama.
The Opelika Post Office was listed on the National Register of Historic Places in 1976. It currently serves as a courthouse for the United States District Court for the Middle District of Alabama.