Tyrone Anthony Holmes (born September 10, 1993) is an American former professional football player who was a linebacker in the National Football League (NFL). He was selected by the Jacksonville Jaguars in the sixth round of the 2016 NFL draft. He played college football for the Montana Grizzlies.
Holmes was selected by the Jacksonville Jaguars in the sixth round with the 181st overall pick in the 2016 NFL draft. On September 3, 2016, he was released by the Jaguars.
Holmes was claimed off waivers by the Cleveland Browns on September 4, 2016.
On September 3, 2017, Holmes was waived by the Browns, but was re-signed on September 7. He was waived again on September 16, 2017, and re-signed to the practice squad. He was promoted to the active roster on November 21, 2017. He was waived on December 13, 2017.
On December 14, 2017, Holmes was signed to the Kansas City Chiefs' practice squad. He signed a reserve/future contract with the Chiefs on January 10, 2018. He was waived on September 1, 2018.
In December 2018, Holmes signed with the San Antonio Commanders of the Alliance of American Football (AAF) before departing the team to join the Los Angeles Chargers practice squad.
On December 26, 2018, Holmes was signed to the Los Angeles Chargers practice squad.
Holmes returned to the Commanders on January 22, 2019.
After the AAF suspended football operations, Holmes signed with the Miami Dolphins on April 9, 2019. He was released on August 31, 2019.