The tyrT operon is a series of genes encoding the tRNA for tyrosine in Escherichia coli. It is activated in response to amino acid starvation.
The tyrT operon consists of an upstream activation sequence, the gene for the tyrosine tRNA called tRNA<sub>1</sub><sup>Tyr</sup>, and an RNA called rtT RNA which has an unknown function.
Transcription of the tyrT operon is activated by the stringent response. Binding of the FIS protein to the operon's upstream activation sequence tightly bends the DNA, promoting transcription.