The Tylihul () is a river in the Odesa Oblast of southern Ukraine. It is 168 km long, up to 10âÂÂ20 m wide, with a watershed of 3,550 km<sup>2</sup>. Its source is in the Podilian Upland and it flows through a narrow (1.0âÂÂ1.5 km wide) valley to the Black Sea depression, where the valley widens up to 3 km. The river inflows to the Tylihul Estuary.
The name of the river comes from the name of the water body into which it flows, the Tylihul Estuary, , which means "mad or rabid lake".