Tylecodon leucothrix is a species of Tylecodon native to Eastern Little Karoo in South Africa. It was first described in by Toelken in 1978.
Its flowers grow on a short stick, and are like many Tylecodon flowers. They have tubular flowers, usually white or pink, and the flowers have petals that bend outwards.
Tylecodon leucothrix is a caudiciform plant with fuzzy leaves. This plant goes dormant in the summer and has pentucles that are slightly sharp, likely to discourage herbivores.