Twin Creek is a stream in the U.S. state of Ohio. The long stream is a tributary of Great Miami River. Aukerman Creek, Bantas Fork, Lesley Run, Millers Fork, Price Creek, Swamp Creek, and Toms Run are tributaries of Twin Creek.
Twin Creek was so named by the Potawatomi Indians on account of its branches.
At its mouth, the creek's estimated mean annual flow rate is . A USGS stream gauge on the creek near Germantown recorded a mean annual discharge of during water years 1921-2019. The highest daily mean discharge during that period was on January 22, 1959. The lowest daily mean discharge was on September 25, 1941.