Tubutama is a town in the north-west of the Mexican state of Sonora. It serves as the seat for the surrounding municipality of the same name.
The municipal area is , and the population was 1,798 in 2005. The main economic activities are cattle raising (11,000 head in 2005) and subsistence farming.
Eusebio Kino, SJ, founded Mission San Pedro y San Pablo del Tubutama in 1691. Tubutama was the headquarters of religious administration for the entire PimerÃÂa Alta during much of the Jesuit and Franciscan period of Spanish colonial rule.