Tsentralnyi District () may refer to the following places in Ukraine:
- Tsentralnyi District, Dnipro, urban district of Dnipro
- Tsentralnyi District, Kherson, urban district of Kherson
- Tsentralnyi District, Mariupol, urban district of Mariupol
- Tsentralnyi District, Mykolaiv, urban district of Mykolaiv
- Tsentralnyi District, Odesa, urban district of Odesa
- Tsentralnyi District, Simferopol, urban district of Simferopol