The Zakarpattia Lowland (; ) or Upper Tysa Lowland ( is a lowland in the southwestern portion of the Zakarpattia Oblast in the drainage basin of Tisza river and located on its right banks. The plain stretches along the Hungary-Ukraine border.
The lowland has an area of . Average height is , while maximum is (Berehove Hills).
The lowland contains most of the population of region and includes all its major cities such as Uzhhorod, Mukachevo, Berehove, Vynohradiv and others.