In enzymology, a trans-epoxysuccinate hydrolase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are trans-2,3-epoxysuccinate and H<sub>2</sub>O, whereas its product is meso-tartrate.
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is trans-2,3-epoxysuccinate hydrolase. Other names in common use include trans-epoxysuccinate hydratase, and tartrate epoxydase. This enzyme participates in glyoxylate and dicarboxylate metabolism.