Toxopneustes is a genus of sea urchins from the tropical Indo-Pacific. It contains four species. They are known to possess medically significant venom to humans on their pedicellariae (tiny claw-like structures). They are sometimes collectively known as flower urchins, after the most widespread and most commonly encountered species in the genus, the flower urchin (Toxopneustes pileolus).
Species included in the genus are the following: