Tick Creek is a tributary of the Gasconade River in northwestern Phelps County in the Ozarks of Missouri.
The stream headwaters are approximately four miles west of Rolla at . The stream flows west passing north of Doolittle then turns north and on to its confluence with the Gasconade on the Phelps-Maries county line at .
Tick Creek most likely was so named due to the reported abundance of ticks in the area.