Thompson River is the largest tributary of the Fraser River, flowing through the south-central portion of British Columbia, Canada.
Thompson River may also refer to:
Canada
- Thompson River (Notawassi Lake tributary), a river in Lac-Douaire (unorganized territory), MRC Antoine-Labelle, Laurentides (administrative region), Quebec
- Thompson River (De Montigny Lake tributary), a tributary of the Milky River in Quebec; see List of rivers of Quebec#Quebec rivers flowing in Ontario (or tributaries of Ontario rivers)
- Thompson River (Franquelin River tributary), a tributary of the Franquelin River in Franquelin, Manicouagan, Côte-Nord, Quebec
- Thompson River Salish, the northern branch of the Thompson River in British Columbia
United-States
See also