Thomas McCain (born c. 1827) was an American politician from DeSoto County, Mississippi. An African-American officeholder during the Reconstruction era, he represented DeSoto County in the Mississippi House of Representatives from 1872 to 1875 and was appointed lieutenant colonel of the county militia.
McCain was born in Tennessee. By 1870 he was living in DeSoto County, Mississippi, where federal census records list him with his wife, Tabitha, and their children.
He represented DeSoto County in the Mississippi House of Representatives from 1872 to 1875. He was an officer in the county militia.
He was married and had children.