The Pirates of the Mississippi () is a novel by the German writer Friedrich Gerstäcker, published in three volumes by in Leipzig in 1848. It revolves around a gang of river pirates led by the charismatic Captain Kelly, who operate from an island in the Mississippi River, have infiltrated the nearby town of Helena, Arkansas, and rob flatboats passing by. It was published in English by Routledge in 1856.
The book was the basis for the 1963 film The Pirates of the Mississippi directed by Jürgen Roland.