The Affair of the Poisons (French: L'affaire des poisons) is a 1907 historical play by the dramatist Victorien Sardou. It portrays the events of the real-life Affair of the Poisons during the reign of Louis XIV and the downfall of his mistress Madame de Montespan. It was Sardou's final play.
In 1955 it was made into a French-Italian film of the same title directed by Henri Decoin and starring Danielle Darrieux, Viviane Romance and Paul Meurisse.