Tezozomoc () was the second tlatoani (ruler) of altepetl Ecatepec, in 15th-century Mesoamerica.
Tezozomoc was a son of an Aztec tlatoani Chimalpopoca, ruler of Tenochtitlan. His mother may have been Matlalatzin.
He was a grandson of tlatoani Huitzilihuitl and Ayauhcihuatl, who was a daughter of the Tepanec tlatoani Tezozomoc, ruler of Azcapotzalco.
He was a relative of and successor tlatoani to Chimalpilli I in 1465. His successor was Matlaccohuatl.