Tetraprenyl-ò-curcumene synthase (EC 4.2.3.130, ytpB (gene)) is an enzyme with systematic name all-trans-heptaprenyl-diphosphate diphosphate-lyase (cyclizing, tetraprenyl-ò-curcumene-forming). This enzyme catalyses the following chemical reaction
This enzyme is isolated from Bacillus subtilis.