The Tete Des Morts Creek is a stream that flows for between Dubuque County and Jackson County in Iowa. The only town in the drainage basin is St. Donatus.
The name Tete Des Morts translates from French as "Head of Death".
Julien Dubuque used the area around to get access to the land from the Spanish Empire. His lease from the Sauk and Meskwaki used the Tete Des Morts as a boundary. In modern times, 98% of the watershed was dedicated to agriculture.