Terence or Terrence O'Brien may refer to:
- Terence O'Brien (bishop) (1600âÂÂ1651), Irish Roman Catholic bishop of Emly
- Terence O'Brien (British Army officer, died 1865), British Army officer and acting governor of Ceylon
- Sir Terence O'Brien (colonial administrator) (1830âÂÂ1904), British Army officer and governor of Newfoundland, 1889âÂÂ1895, son of the above
- Terence O'Brien (actor) (1887âÂÂ1970), Irish-born British actor
- Terence O'Brien (rower) (1906âÂÂ1982), English Olympic rower
- Terence O'Brien (British diplomat) (1921âÂÂ2006), British ambassador to Nepal, 1970âÂÂ1974, Burma, 1974âÂÂ1978, and Indonesia, 1978âÂÂ1981
- Terence O'Brien (New Zealand diplomat) (1936âÂÂ2022), New Zealand ambassador to the United Nations, 1980âÂÂ1983, 1990âÂÂ1993, and the European Community, 1983âÂÂ1986
- Terrence L. O'Brien (born 1943), United States federal judge
- Terrence O'Brien (director) (born 1953), American founder and director of the Hudson Valley Shakespeare Festival