2,3,4,6-Tetramethoxyphenethylamine (2,3,4,6-TeMPEA), also known as TeMPEA-2, is a drug of the phenethylamine family related to the psychedelic drug mescaline (3,4,5-trimethoxyphenethylamine). It is one of the possible positional isomers of tetramethoxyphenethylamine (TeMPEA). The in-vitro metabolism and effects of TeMPEA-2 on behavior in animals have been studied. The drug showed little or no activity as a norepinephrine releasing agent in vitro. It does not seem to have been tested in humans. TeMPEA-2 was first described in the scientific literature by 1955. It is a controlled substance in Canada under phenethylamine blanket-ban language.