The Tarkhan dynasty () ruled Sindh from 1554 to 1593. General Mirza Isa Beg, a Tarkhan, founded the dynasty after the death of Shah Husayn Arghun of the Arghun dynasty.
The Mughal emperor Akbar annexed Sindh in 1593 after defeating the last Tarkhan ruler, Mirza Jani Beg; Jani Beg and his son Mirza Ghazi Beg continued to rule as Governors for the Mughals.
The Arghun rulers have their tombs at the Makli Necropolis.
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