Tamale Central is one of the constituencies represented in the Parliament of Ghana. It elects one member of parliament (MP) by the first-past-the-post system of election. Tamale Central is located in the Tamale Metropolitan district of the Northern Region of Ghana.
This seat was created prior to the Ghanaian parliamentary election in 2004.
At the by-election held on 4 April 2006, Alhassan Fuseini Inusah of the National Democratic Congress (NDC) won with a majority of 17502. This followed the resignation of Alhassan Wayo Seini (NDC), who resigned to join the New Patriotic Party but lost the resultant by-election.
The seat is located within the Tamale Municipal district of the Northern Region of Ghana.
Alhassan Wayo Seini who was the sitting MP in 2006 left the NDC to join the New Patriotic Party. This triggered a by-election. He stood for the by-election as an independent candidate but lost his seat to who the NDC nominated as his replacement.
The 2025 by-election was called after the death of Ibrahim Murtala Muhammed in a helicopter crash. The Electoral Commission set 30 September 2025 as the date for the by-election. The New Patriotic Party opted not to contest the election. Three candidates filed to contest the election. They were Alidu Mahama Seidu of the NDC, Ibrahim Mohammed Hafiz of the Liberal Party of Ghana (LPG) and Alidu Mohammed Nasir-deen of the People's National Convention (PNC). Later on the same day, the LPG and PNC candidates withdrew their candidaces. The Electoral Commission reopened nominations for the by-election following the withdrawals. No new candidates came forward so Alidu Mahama Seidu was declared elected unopposed on 30 September 2025 by the Electoral Commission.